| 肢体缺血预处理对大鼠坏死心肌的保护作用 |
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| 引用本文： | 徐婷,李春耕. 肢体缺血预处理对大鼠坏死心肌的保护作用[J]. 河北北方学院学报(医学版), 2008, 25(3) |
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| 作者姓名： | 徐婷 李春耕 |
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| 作者单位： | 1. 中国人民解放军第401医院,山东,青岛,266071
2. 河北省唐山市中医院,河北,唐山,063000 |
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| 摘 要： | 目的:研究肢体缺血预处理(LIP)对大鼠缺血再灌后心脏损伤的影响。方法:采用反复捆绑后肢造成缺血预适应的方法,观察其对心肌缺血再灌后梗死面积和形态学改变的影响,对心肌CK-MB和cTn-I的影响,以及对抗氧化物酶的影响。结果:与缺血再灌组比较,预处理能明显降低心肌梗死面积,减轻心肌细胞的损害,减少心肌酶的漏出并能提高SOD的活性。结论:LIP对心肌损伤具有保护作用。
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| 关 键 词： | 四肢 缺血预处理 CK-MB cTn-I 超氧化物歧化酶 |
The Protection Function of Limb IschemicPreconditioning to Myocardial Injury in Rats |
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| XU Ting,LI Chun-geng. The Protection Function of Limb IschemicPreconditioning to Myocardial Injury in Rats[J]. Journal of Hebei North University:Medical Edition, 2008, 25(3) |
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| Authors: | XU Ting LI Chun-geng |
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| Abstract: | Objective:To investigate the effect of limb ischemic preconditioning(LIP)on the myocardial ischemia-reperfusion(I/R)injury in rats.Methods:By ischemic preconditioning in hind limb to make the model,then investigate the effect on myocardial infarct size and morphologic change,and also on the enzyme of CK-MB and cTn-I.The activity of SOD after myocardial I/R was observed as well.Results:Compared with I/R,the myocardial infarct size was reduced,the myocardial injury was attenuated,the leakage of CK-MB and cTn-I was decreased and the activity of SOD was increased after pretreated with LIP.Conclusion:LIP has protection function on myocardial injury. |
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| Keywords: | Extremities Ischemic Preconditioning CK-MB cTn-I Superoxide Dismutase |
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