Involvement of Depressive Catecholamines as Thrombosis Risk/Inflammatory Markers in Non-Smoker,Non-Obese Congestive Heart Failure,Linked to Increased Epidermal Growth Factor-Receptor (EGF-R) Production |
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Authors: | Nadia M Hamdy Lamiaa El-Wakeel Salwa M Suwailem |
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Institution: | (1) Biochemistry Department, Faculty of Pharmacy, Ain Shams University, 11566 Abassia, Cairo, Egypt;(2) Clinical Pharmacy Department, Faculty of Pharmacy, Ain Shams University, 11566 Cairo, Egypt;(3) Cardiology Department, Faculty of Medicine, Ain Shams University, 11566 Cairo, Egypt |
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Abstract: | The EGF-R, also known as HER-1 or erbB-1 (EGF-R/HER-1/erbB-1), is a member of the human epithelial receptor tyrosine kinase
family. sEGF-R is considered to play a role in cardiac (patho)physiology. We aimed to investigate whether soluble EGF-R is
increased in congestive heart failure (CHF) patients and if related to disease severity. Soluble EGF-R, vitamin D, parathyroid
hormone (PTH) was studied, and being evaluated in relation to Ca2+, lipids, hsCRP, fibrinogen, serotonin, norepinepherine (NE). The study compared non-smoker, non-obese male CHF patients (n = 50) with age and gender-matched essential hypertension (HTN) patients (n = 20). Moreover, comparison with healthy control volunteers (n = 20) were employed. EGF-R/HER-1/erbB-1 was higher (P = 0.013) in 50 CHF male patients mean 12 ± 0.7 fmol/ml, than in 20 HTN, 9.25 ± 0.6 fmol/ml or in 20 controls, 6.25 ± 1 fmol/ml.
Serum EGF-R levels correlated positively with hsCRP and NE, and were highest among CVD patients (n = 70) as well as negatively with vitamin D and HDL-C. EGF-R/HER-1/erbB-1 levels are increased in HTN and more in CHF patients.
This study confirms a strong association between catecholamines as well as EGF-R/HER-1/erbB-1 levels with PTH and low vitamin
D levels, being related to hyperlipidemia and inflammation (hsCRP and fibrinogen) in CVD. Moreover, contributing to the complex
process of the inflammatory component of atherosclerosis in hypertensive patients that leads eventually to CHF. |
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Keywords: | CHF 25-hydroxy vitamin D Fibrinogen Depression Catecholamines EGF-R/HER-1/erbB-1 |
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