| 白芍总甙对大鼠酒精性肝损伤保护作用的实验研究 |
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| 引用本文： | 李莲.白芍总甙对大鼠酒精性肝损伤保护作用的实验研究[J].孝感职业技术学院学报,2010,13(1):105-109,53. |
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| 作者姓名： | 李莲 |
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| 作者单位： | 湖北职业技术学院医学院,湖北孝感432000 |
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| 摘 要： | 目的：探讨白芍总甙对实验性大鼠酒精性肝损伤的保护作用及其作用机制。方法：SD大鼠随机分为3组：模型组（M组）、生理盐水对照组（N组）、白芍总甙处理组（B组），每组10只。M组大鼠予56°白酒连续灌胃4周制造酒精性肝损伤模型；B组在白酒灌胃基础上给予白芍总甙0．4mg／100g体重灌胃；N组予生理盐水灌胃。第4周末处死大鼠后检测血清ALT、AST、γ-GT、SOD、MDA水平，光镜下观察肝组织细胞形态学改变，用免疫组化方法测定肝细胞核中NF-κB的表达。结果：模型组大鼠血清ALT、AST、γ-GT、MDA水平明显升高；白芍总甙处理组大鼠血清ALT、AST、γ-GT、MDA轻度升高，但明显低于模型组，与生理盐水对照组相比无显著性差异。模型组大鼠血清SOD水平明显降低，白芍总甙处理组与生理盐水对照组血清SOD水平明显高于模型组。模型组肝细胞脂肪变性、坏死、炎性细胞浸润等改变均较白芍总甙处理组及对照组明显。白芍总甙处理组NF-κB的表达低于模型组。结论：白芍能改善肝功能，对实验性大鼠酒精性肝损伤具有保护作用，其机制可能与降低脂质过氧化水平，提高抗氧化酶活性，抑制NF-κB的活化有关。
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| 关 键 词： | 白芍总甙 酒精性肝损伤 脂质过氧化 |
Experimental Research on the Protection of TGP on Alcoholic Liver Injury in Rats |
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| LI Lian.Experimental Research on the Protection of TGP on Alcoholic Liver Injury in Rats[J].Journal of Xiaogan Vocational-Technical College,2010,13(1):105-109,53. |
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| Authors: | LI Lian |
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| Institution: | LI Lian(Hubei Polytechnic Institute,Xiaogan,Hubei 432000,China) |
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| Abstract: | Objects :To study the protection of TGP on chronic alcoholic liver injury in rats and to discuss the mechanism.Methods:30 SD rats were divided randomly into three groups,the 10 rats of model group were given alcohol intragastrically for four weeks to prepare rat model of chronic alcoholic liver injury.The TGP treatment group rats were given alcohol and TGP intragastrically.The group treated with Saline rats were given normal Saline intragastrically for four weeks.At the end of 4th week all rats were killed ... |
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| Keywords: | TGP alcoholic liver injury lipid peroxidation |
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