The effects of rapid eye movement sleep deprivation and recovery on spatial reference memory of young rats |
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Authors: | Shenghui Li Ying Tian Yu Ding Xinming Jin Chonghuai Yan and Xiaoming Shen |
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Institution: | (1) Department of Psychology, Neuroscience Program, University of British Columbia, Vancouver, BC, Canada;(2) Department of Biology, McCardell Bicentennial Hall, Middlebury College, Middlebury, VT 05753, USA |
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Abstract: | It is known that rapid eye movement (REM) sleep plays a crucial role in learning and memory. Previous studies have demonstrated
that postlearning REM sleep deprivation (RSD) impairs memory consolidation. Most of these studies observed only the effects
of RSD on learning and memory. In the present study, we not only investigated the impacts of 48-h RSD on the spatial reference
memory of young rats in a Morris water maze, but also specifically examined whether an REM rebound for 24–48 h after 48-h
RSD affected the maintenance of spatial reference memory. RSD was induced by the modified multiple platform method, and spatial
reference memory was tested in a Morris water maze. The results demonstrated that, compared with the control groups, posttraining
RSD for 48 h produced a significant impairment in the retention of acquired spatial reference memory, and the impairment continuously
existed after 24 and 48 h of release from sleep deprivation, which indicates that REM sleep plays a critical role in reference
memory maintenance and consolidation. Moreover, postlearning RSD may lead to a long-term impairment in the consolidation of
newly acquired memories. |
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Keywords: | |
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