| 从HEPC基因筛选预测有氧耐力训练对左心室功能影响的分子标记 |
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| 引用本文： | 乌云格日勒,胡扬,李燕春,聂晶,高莹. 从HEPC基因筛选预测有氧耐力训练对左心室功能影响的分子标记[J]. 北京体育大学学报, 2010, 0(3) |
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| 作者姓名： | 乌云格日勒 胡扬 李燕春 聂晶 高莹 |
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| 作者单位： | 内蒙古师范大学体育学院;北京体育大学;江西师范大学体育学院; |
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| 基金项目： | 科技部奥运攻关课题(2006BAK12B01) |
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| 摘 要： | 目的:通过HEPC基因SNP/A2032G多态性与有氧耐力训练后左心室功能指标训练敏感性的关联性分析,从HEPC基因中筛选预测有氧耐力训练效果的分子标记,为制定个性化有氧耐力训练方案提供科学依据。方法:对102名中国北方平原地区健康男子进行为期18周的有氧耐力训练,使用超声心动仪测定其训练前后安静状态和递增负荷运动下的左心室功能指标,应用PCR-RFLP技术解析受试者SNP/A2032G多态性。采用association studies with training response phenotypes方法分析SNP/A2032G多态性与训练前后左心室功能指标的关联性。结果:经18周有氧耐力训练后,AG型150W/SV、150W/SVI和150W/EF的训练敏感性最高。其中,AG型群体的150W/SV、150W/SVI增加量显著高于GG型,且存在高于AA型的趋势;AG型群体的150W/EF增加量显著高于GG和AA型。结论:HEPC基因SNP/A2032G的AG型可作为预测有氧耐力训练后心室功能指标训练敏感性的分子标记。
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| 关 键 词： | Hepcidin 基因多态性 有氧耐力训练 |
To Select the Genetic Markers for Response to Left Ventricular Functions for Aerobic Training in HEPC Gene |
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| Wuyun Gerile,HU Yang,LI Yan-chun,NIE Jing,GAO Ying. To Select the Genetic Markers for Response to Left Ventricular Functions for Aerobic Training in HEPC Gene[J]. Journal of Beijing Sport University, 2010, 0(3) |
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| Authors: | Wuyun Gerile HU Yang LI Yan-chun NIE Jing GAO Ying |
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| Affiliation: | 1.College of Physical Education;Inner Mongolia Normal University;HHHOT 010022;China;2.Beijing Sport University;Beijing 10084;3.College of Physical Education;Jiangxi Normal University;Nanchang 330027;Jiangxi China |
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| Abstract: | To study on association between SNP/A2032G polymorphism in HEPC gene and response to left ventricular functional parameters after aerobic training,in order to screening genetic markers of aerobic training and provide evidence to genetic individual program.102 health males were completed 18 weeks aerobic training.Echocardiography was used to measured parameters of left ventricular functions on resting state in before and after training,and loading movement also.The PCR-RFLP was used to analyze the gene polym... |
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| Keywords: | Hepcidin gene polymorphism aerobic training |
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