磷脂微管的制备及显微观察

以改性磷脂联乙炔基甘油磷脂酰乙二醇为原料,用分子自组装方法制备了脂类微管,并对其结构进行了显微分析。研究表明,微管的形成与分子的手性有关。SEM和TEM结果显示,自组装微管的生成率很高,外观呈弯曲螺状结构,具有很高的长径比,平均长度为380μm,平均直径为110 nm;脂类微管可用作载体包埋海洋防污剂或药物,控制它们的释放,可望用于新型功能材料的开发。

Preparation and Microscopic Observation of Phospholipid Microtubules

Lipid microtubules are prepared by a self-assembly method from diacetylenic glycerol phosphatidylhydroxyethanol.The study indicates that the formation of lipid microtubules is relative to the chirality of molecules.The results of SEM and TEM show that there is a high yield of microtubules in the self-assembly from modified lipid molecules and they present a wrapped helical structure with a high aspect ratio.Their average length is 380μm,and the average diameter is 110 nm.Lipid microtubules can be used as a vehicle to encapsulate marine antifouling agents or drugs in its lumen to control their release.Hence,metallized microtubules can be pontential to be developed for novel micro-and nano-meter functional materials.