| 辛可宁分子印迹纳米球的制备及药物释放性能研究 |
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| 引用本文： | 黄少梅,杨万里,史艳芳,何建峰.辛可宁分子印迹纳米球的制备及药物释放性能研究[J].顺德职业技术学院学报,2012(4):1-4. |
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| 作者姓名： | 黄少梅 杨万里 史艳芳 何建峰 |
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| 作者单位： | 广州中医药大学中药学院 |
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| 摘 要： | 以辛可宁为模板分子(T),甲基丙基酸(MAA)为功能单体,甲基丙基酸甲酯(MMA)为调节剂,乙二醇二甲基丙烯酸酯(EDMA)为交联剂,采用沉淀聚合法制备得到均匀球形纳米分子印迹聚合物。当MIP组成为nMAA∶nMMA∶nEDMA=2∶7∶7∶10时,其平均粒径为580 nm,平衡吸附与释放实验表明该聚合物不仅对辛可宁有较好的分子识别性能,而且还具有良好的药物缓释性能。
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| 关 键 词： | 分子印迹 辛可宁 药物识别与释放 |
Study on the Preparation of Cinchonine Molecularly Imprinted Nano-spheres and Its Properties on the Drug Release |
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| Authors: | HUANG Shao-mei YANG Wan-li SHI Yan-fang HE Jian-feng |
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| Institution: | *(School of Chinese Pharmaceutical Science,Guangzhou University of Chinese Medicine,Guangzhou Guangdong 510006,China) |
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| Abstract: | In the current research, the uniformly sized molecularly imprinted nano-s precipitation polymerization using cinchonine as the template, methacrylic acid （MAA pheres were prepared by a ） as a functional monomer, methylmethacrylate （MMA） as the regulator and ethylene glycol dimethacrylate （EDMA） as cross-linker, respectively. When the ratio of nMAA： nMMA： nEDMA was 2：7：7：10, the average particle diameter of the imprinted polymer is about 580 nm. The equilibrium adsorption and release experiment indicated that the imprinted polymer not only possessed a good molecular recognition effect toward template, but also had a sustained releasing ability. |
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| Keywords: | molecular imprinting cinchonine drug recognition and release |
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