苯并呋咱-N-氧化物及其衍生物合成工艺研究概况

苯并呋咱-N-氧化物及其衍生物的合成研究取得了很大进展,特别是采用次氯酸钠氧化邻硝基苯胺的合成方法和生产工艺呈现出许多不同的特点.这类合成以邻硝基苯胺一类化合物为原料,在碱金属氢氧化物催化作用下,用次氯酸钠氧化合成得到苯并呋咱-N-氧化物(BFO)或其衍生物.合成工艺研究多致力于降低原材料成本、提高生产的安全性、减少对生产环境的污染以及解决三废问题,同时使合成条件更加缓和,生产工艺更趋于合理,特别是在减少溶剂副反应,降低溶剂消耗等方面,各种工艺表现出不同特点.其中包括以乙醇、甲醇为溶剂的方法、甲苯或苯等为溶剂的相转移催化方法,直到以水、表面活性剂聚乙二醇等为反应介质合成BFO的方法.

Outline of the Research in Synthesis of Benzofuroxan and it's Derivatives

Great development has been made in recent years in the study on the syntheses of benzofuroxan(BFO) and its derivatives,especially on the synthesis methods and techniques of oxidizing 2-nitroaniline or its derivatives with sodium hypochlorite.In such synthesis,2-nitroaniline or its derivatives is used as reacting agent and sodium hypochlorite as oxidant in the catalysis of alkali metal hydrates to synthesize BFO or its derivatives.The study is generally focused on cost and pollution reduction,safety improvement,and waste treatment.In the meantime,the working conditions are made less strict for the production process to be more rational,especially in the aspects of reducing degree of by-reaction and consumption of solvents,etc,different methods have their special characteristics.The techniques include the method where ethanol or methanol is taken as solvents,phase transfer catalysis toluene or benzene,water with surfactants as mediate,and so on.The studies of syntheses of benzofuroxan(BFO) and its derivatives are reviewed.