Antidiabetic and ameliorative potential of Ficus bengalensis bark extract in streptozotocin induced diabetic rats |
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Authors: | Mahalingam Gayathri Krishnan Kannabiran |
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Institution: | (1) School of Biotechnology, Chemical and Biomedical Engineering, VIT University, Vellore, 632 014, Tamil Nadu, India;(2) Biomolecules and Genetics division, School of Biotechnology, Chemical and Biomedical Engineering, VIT University, Vellore, 632014, Tamil Nadu, India |
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Abstract: | The aim of the present study was to evaluate the antidiabetic and ameliorative potential of aqueous extract of Ficus bengalensis
bark in streptozotocin induced diabetic rats. The effect of oral administration of aqueous extract of F. bengalensis bark
on blood glucose, serum electrolytes, serum glycolytic enzymes, liver microsomal protein, hepatic cytochrome P-450 dependent
monooxygenase enzymes and lipid peroxidation in liver and kidney of streptozotocin -induced diabetic rats was studied. Oral
administration of Ficus bengalensis to fed, fasted and glucose loaded diabetic rats significantly F > 0.05 (ANOVA) and P<
0.05 (DMRT)] decreased the blood glucose level at 5 hrs and restored the levels of serum electrolytes, glycolytic enzymes
and hepatic cytochrome P-450 dependent enzyme systems and decreased the formation of liver and kidney lipid peroxides at the
end of 12 weeks. Further, the aqueous extract of Ficus bengalensis at a dose of 500mg/kg/day exhibits significant antidiabetic
and ameliorative activity as evidenced by histological studies in normal and Ficus bengalensis treated streptozotocin induced
diabetic rats. On the basis of our findings, it could be used as an antidiabetic and ameliorative agent for better management
of diabetes mellitus. |
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Keywords: | Ficus bengalensis Antidiabetic activity Ameliorative potential Cytochrome P-450 dependent monooxygenase enzymes Lipid peroxidation |
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