国内有关硒与癌症发生相关文献的评价

目的:通过对国内有关硒与癌症发生的相关文献进行循证医学评价来了解目前相关文献的质量现状.方法:在生物医学文献数据库中以"硒"和"癌症"为主题词检索建库至2014年6月的相关文献,对检出的文献进行筛选后,利用九级证据评价标准及M量表对所纳入的文献进行评价.结果:九级评价标准:纳入的376篇文献中系统评价/Meta分析的文献为0篇,随机对照试验(RCT)文献33篇,其他343篇.M量表:33篇RCT文献评价结果中4分的文献有3篇,未见大于4分的文献.结论:九级评价结果:目前国内有关硒与癌症关系的研究中,动物研究和体外研究占多数,RCT研究相对较少,系统评价/Meta分析文献未见.M量表评价结果:目前国内有关硒与癌症发生相关文献的质量整体水平不高,在实验研究设计中存在很多问题,有待进一步提高.高质量证据的研究表明硒具有防癌治癌的作用,硒制剂能够增强一些化疗药物的疗效,并且减少化疗或放疗对人体产生的副作用.

Evaluation on Chinese Literature about Selenium and Cancer

Objective: This paper aims to evaluate domestic related literature piovince selenium and cancer. Methods: Literatures published chinese untill June, 2014 about the relationship between selenium and cancer in the Chinese Biomedical Literature Database by using selenium and cancer as the keywords. Take advantage of the nine-level standard of proof of Evidence-Based Medicine and M scale to make an evaluation on the selected literatures.Results: Nine evaluation criteria: 376 documents include. 0 systematic reviews / meta analysis,33 RCTs, and 343 are others, M scale among:33 RCTs : 3 RCTs are scored 4; and no RCTs are more than 4. Conclusion: The assessment result of the nine-level standard of proof of Evidence-based Medicine show: at present, animal research and in vitro study are the majority; RCTs are relatively minority; there is no systematic reviews/meta analysis of the literatures; in the domestic research about selenium and cancer. According to the M scale, the qualities of the domestic literatures about selenium and cancer are not high. There are many short comings in the experimental study design and will be further improved. High-quality research evidence suggests that selenium has the effective effects on anti-cancer and treatment of cancer. Selenium preparation can enhance the efficacy of some chemotherapy drugs and reduce the side effects on the human body with chemotherapy or radiotherapy.