杭州市1319名正常成年人骨密度测定分析

对杭州市1319名正常成年人尺、桡骨骨密度(BMD)的测定结果进行分析,发现性别与增龄因素对BMD有显著影响,BMD随增龄而变化的特点是女性达峰早、下降快,男性达峰迟、下降慢.正常成年人男性BMD比女性高(P<0.01).一般性OP发病率随增龄而上升,但性别差异不显著(P>0.05).基于尺骨BMD与桡骨BMD差异不显著(P>0.05),加之这二项BMD指标与尺桡骨平均BMD相互间均呈高度正相关关系(P<0.01),所以将尺桡骨平均BMD这一单项指标作为活体骨矿物含量的综合评定指标是可行的.本研究还表明在女性体重指数(BMI)与BMD之间有正相关关系存在(P<0.05),提示消瘦可能是女性OP发病的危险因子.

Determination and Analysis of Bone Mineral Density in 1319 Normal Adults in Hangzhou

This paper presents the results of bone mineral density (BMD) in 1319 normal adults. The results showed: 1. BMD was significantly influenced by sex and increasing age. In the variation of features of BMD with increasing age, the females reach the peak value earlier and descend faster than that of the males. 2. BMD of normal adult was higher in the male sex than in the female sex (P<0. 01). 3. The incidence of gen- eral osteoporosis (GOP) was elevated with increasing age, but no significant difference between both sexes could be demonstrated. 4. As the difference between BMD of ulna and radius was of no statistic significance, in addition, the two BMD markers were highly proportional to the mean BMD of ulna and radius (P<0. 01), therefore, the authors suggested that the mean BMD of ulna and radius (this single marker) could be regard- ed as a general indication which evaluated the vivi-bone mineral content (vivi-BMC). 5. There is a direct re- lationshop between body mass index (BMI) and BMD in female (P<0. 05). It is indicated that emaciation may be a risk factor of OP pathogenesis in female.