The inheritance of behavioral wildness in house mice (Mus musculus L.)

Fourteen behavioral measures were ranked according to their ability to differentiate performances of a wild population of mice from three domestic inbred strains. These “wildness” rankings were then analyzed for their ability to predict genetic and Genotype by Environment interactions. Genetic parameters were derived from analysis of three inbred domestic strains and their three hybrid crosses via the diallel technique of genetic analysis. Genotype by Environment interactions were assessed both as mean differences in stock performances resulting from rearing in a laboratory vs naturalistic environment and as differences in environmental variability within stock genotypes. Behavioral characters ranking high on “wildness” failed to demonstrate any unitary pattern of Genotype by Environment interactions. The diallel genetic analysis revealed many examples of additive variation but relatively few examples of dominant variation. An extremely wide range of interactions occurred between genotype and rearing environments, with “wildness” and “developmental homeostasis” concepts both failing to account for all the observed interactions.