薄荷油对小鼠肝肾损伤的动物实验研究

目的：从病理学形态改变的角度探索薄荷提取液对肝脏和肾脏的损伤作用。方法：实验以昆明小白鼠为研究对象，将其随机分组，采用灌胃的方法给予不同剂量薄荷油。从病理学角度观察其肝、肾器官形态改变，以了解该植物提取液的毒性和致死量。结果：通过急性实验，发现大剂量薄荷油对小白鼠的肝、肾均有损伤作用，随着剂量的增加，病理变化随之明显。组织切片显示肝细胞水肿和脂肪变性，肾小管上皮也可见一定的损伤，表现为上皮细胞水肿。结论：大剂量薄荷油对小鼠的肝、肾均有损伤作用，肝毒性显著，并对肾脏有轻度毒性。

Liver and Kidney Damage Induced by Peppermint Oil on Mice Model

Objective： To investigate the injury effect of peppermint extract on mice liver and kidney using pathological method. Methods： Kunming mice subjected peppermint oil by intragastrical way were randomized in to different peppermint oil doses groups. Pathological alternations were observed and the amounts of lethal and toxicity of plant extracts were examined. Results： With acute experiments, we found that large doses of peppermint oil could induce mouse liver and kidney damage, and with the dose increased, pathological changes were severe.Tissue slices showed edema and fatty degeneration on liver cells, and edema on the kidney epithelial cells. Conclusion： Large doses of peppermint oil were damage to both mouse liver and kidney,but in different extents.