碘化钠促进的2-溴代苯并呋喃的氰化反应研究

2-氰基苯并呋喃类化合物通常具有很强的生物活性，常用于药物分子和天然产物的构建。2-溴苯并呋喃类化合物在碘化钠做促进剂的条件下与氰化亚铜发生氰化反应，一步得到2位被氰基取代的呋喃衍生物。该方法实现了无过渡金属催化剂的溴代杂环化合物的氰化反应，有效减少了过渡金属催化剂对产品的污染。

Study on the Sodium Iodide Promoted Cyanation of 2-Bromobenzofurans

2-Cyanobenzofurans were widely utilized in the construction of pharmaceutical molecules and natural products for their high bioactivities. A series of 2-cyanobcnzofurans were obtained in high yields through the cyanation of 2-bromo- benzofurans under the conditions of sodium iodide as promoters and cuprous cyanide as cyanating reagents. This method has realized the cyanation of heterocyclic bromide under transition metal catalyst free conditions and avoided the contami- nating of products from transition metal catalyst successfully.