Plasma proteinase inhibitory activity in ectopic and molar pregnancy |
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Authors: | Maya Roche V P Arun Kumar S M Ibrahim K Nalini |
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Institution: | (1) Department of Biochemistry, Melaka Manipal Medical College, Manipal, India;(2) Kasturba Medical College, Manipal, Karnataka, India;(3) Department of Biochemistry Melaka Manipal Medical College, International Centre for Health Sciences, Manipal, 576104, Karnataka, India |
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Abstract: | Antitryptic, antichymotryptic and alpha 2- macroglobulin activities were measured in sera of normal nonpregnant and normal
pregnant women and women with tubal ectopic pregnancy and molar pregnancies in the first 5 to 7 weeks of pregnancy calculated
from the last menstrual period. While alpha 2-macroglobulin decreased in early normal pregnancy compared to nonpregnant state
(p<0.001), in ectopic and molar pregnancies there was an increase in alpha 2- macroglobulin activity (p < 0.001), as compared
to nonpregnant and normal pregnant women. Antitryptic activity did not increase in normal and ectopic pregnancy, however was
increased in molar pregnancy (p < 0.01). Antichymotryptic activities did not show a change either in normal pregnancy or in
cases of ectopic and molar pregnancy. Drop in alpha 2- macroglobulin activity to near normal levels in ectopic, 6 weeks post
surgery, correlated well with the decrease in β-hCG. However, in molar pregnancy, alpha 2- macroglobulin remained elevated
even when the β-hCG levels in serum returned to zero 10 weeks after surgery. The studies suggest a major role for circulating
proteinase inhibitors especially alpha 2-macroglobulin in regulating proteinase activity in normal, ectopic and molar pregnancy. |
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Keywords: | Antitryptic Antichymotryptic Alpha 2 - macroglobulin Molar Ectopic |
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