| 云南甘草总皂甙对氧自由基诱导羊心肌细胞膜Na~+,K~+-ATP酶活性降低的保护作用 |
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| 引用本文： | 刘磊,高卫,李钧波.云南甘草总皂甙对氧自由基诱导羊心肌细胞膜Na~+,K~+-ATP酶活性降低的保护作用[J].大连大学学报,1998(2). |
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| 作者姓名： | 刘磊 高卫 李钧波 |
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| 作者单位： | 大连大学医学院基础部，大连大学医学院基础部，大连市卫校 大连 116622，大连 116622，大连 116622 |
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| 摘 要： | 云南甘草总皂甙对正常羊心肌细胞膜Na~+,K~+-ATP酶活性无影响;但对氧自由基诱导羊心肌细胞膜Na~+,K~+-ATP酶活性的降低有明显保护作用,随浓度增高,酶的活性逐渐升高,与对照组比较,总皂甙浓度为0.2mg·L~(-1)时,酶的活性恢复27.9％,浓度为0.8mg·L~(-1),酶的活性恢复46.6％。
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| 关 键 词： | 云南甘草总皂甙 心肌细胞膜 Na~+ K~+-ATP酶 超氧阴离子自由基 氧自由基发生系统 羟自由基 |
Effects of Saponins of Glycyrrhiza Yunnanensis on the Decrease of Na+, K+-ATPase Activity Induced by Oxygen Free Radicals |
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| Liu Lei.Effects of Saponins of Glycyrrhiza Yunnanensis on the Decrease of Na+, K+-ATPase Activity Induced by Oxygen Free Radicals[J].Journal of Dalian University,1998(2). |
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| Authors: | Liu Lei |
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| Abstract: | The study showed that saponins of gxly - cyrrhiza yunnanensis (SGY) had no significant effects on Na+, K+-ATPase activity in the normal sheep meocardial sarcolemma, but had a significant protective effect on the reduction of Na+, K+-ATPase activity induced by oxygen free radicals. With the increase of SGY concentrations, Na+, K+-ATPase activity was elevated. Compared with the control groups, the emzyme activity increased by 27.9% at 0.2mg · L-1, and 46.6% at 0.8 mg · L-1. |
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| Keywords: | saponins of glycyrrhiza yunnanensis myocardial sarcolemma Na+ K+-ATPase superoxide anion free radical generation system hydroxyl radical |
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