| 跑台训练增强大鼠的学习记忆及其海马BDNF基因表达 |
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| 引用本文： | 徐波,黄涛,季浏.跑台训练增强大鼠的学习记忆及其海马BDNF基因表达[J].北京体育大学学报,2011,34(4):51-53. |
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| 作者姓名： | 徐波 黄涛 季浏 |
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| 作者单位： | 华东师范大学体育与健康学院; |
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| 基金项目： | 教育部留学回国人员科研启动基金资助项目(44760030); 上海市浦江人才计划资助项目(44880240) |
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| 摘 要： | 目的:探讨8周跑台训练对大鼠学习记忆能力及其海马内脑源性神经营养因子(BDNF)基因表达的影响。方法:将24只雄性SD大鼠分为对照组(C组,n=8)和训练组(T组,n=16),T组进行8周的跑台训练。通过Y迷宫实验,所有大鼠在第7周进行学习能力测试,在第8周进行记忆能力测试。第8周最后一次训练后,随机将T组分为T1组(n=8)和T2组(n=8)。T1组训练后即刻与C组同时断头处死,两组交叉进行,T2组在训练后24时断头处死,采用RT-PCR法检测各组大鼠海马内BDNF的基因表达水平。结果:Y迷宫测试表明T组大鼠的学习记忆优于C组;与C组相比,T1组和T2组大鼠海马中BDNF的基因表达水平均显著升高(p<0.01)。结论:8周跑台训练可增强大鼠的学习记忆能力,这与海马内BDNF基因表达的增加有关。
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| 关 键 词： | 跑台训练 大鼠 学习记忆 海马 脑源性神经营养因子 |
Research on the Enhancement of Treadmill Training on Learning-memory and BDNF mRNA Expression in Hippocampus of Rats |
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| XU Bo,HUANG Tao,JI Liu.Research on the Enhancement of Treadmill Training on Learning-memory and BDNF mRNA Expression in Hippocampus of Rats[J].Journal of Beijing Sport University,2011,34(4):51-53. |
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| Authors: | XU Bo HUANG Tao JI Liu |
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| Institution: | XU Bo,HUANG Tao,JI Liu(College of Physical Education and Health,East China Normal University,shanghai,200241,China) |
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| Abstract: | Objective:The purpose of this study is to explore the effects of treadmill training on learning-memory and BDNF mRNA expression in hippocampus of rats.Method: 24 male SD rats were assigned into two groups: control group(C,n=8),training group(T,n=16).The T group rats took part in treadmill training for 8 weeks.In 7th week,all of the rats were participated the learning test by Y maze,and in 8th week,all of the rats were participated the memory test by Y maze.After the last treadmill training in 8th week,T gro... |
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| Keywords: | treadmill training rat learning and memory hippocampus BDNF |
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