| Vascular architecture:is it a helpful histopathological biomarker for hepatocellular carcinoma? |
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| 引用本文： | GRIZZI Fabio,FRANCESCHINI Barbara,FIAMENGO Barbara,RUSSO Carlo,DIOGUARDI Nicola. Vascular architecture:is it a helpful histopathological biomarker for hepatocellular carcinoma?[J]. Journal of Zhejiang University. Science. B, 2007, 0(4) |
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| 作者姓名： | GRIZZI Fabio FRANCESCHINI Barbara FIAMENGO Barbara RUSSO Carlo DIOGUARDI Nicola |
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| 作者单位： | Laboratories of Quantitative Medicine Istituto Clinico Humanitas IRCCS，20089 Rozzano，Milan，Italy，Laboratories of Quantitative Medicine，Istituto Clinico Humanitas IRCCS，20089 Rozzano，Milan，Italy，Department of Pathology，Istituto Clinico Humanitas IRCCS，20089 Rozzano，Milan，Italy，Laboratories of Quantitative Medicine，Istituto Clinico Humanitas IRCCS，20089 Rozzano，Milan，Italy，Laboratories of Quantitative Medicine，Istituto Clinico Humanitas IRCCS，20089 Rozzano，Milan，Italy |
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| 摘 要： | Hepatocellular carcinoma(HCC) remains one of the major public health problems throughout the world.Although originally associated with tumorigenic processes,liver angiogenesis has also been observed in the context of different liver in-flammatory,fibrotic,and ischemic conditions.Here we investigate the fractal dimension as a quantitator of non-Euclidean two-dimensional vascular geometry in a series of paired specimens of primary HCC and surrounding non-tumoral tissue,and discuss why this parameter might provide additional information regarding cancer behavior.The application of fractal geometry to the measurement of liver vascularity and the availability of a computer-aided quantitative method can eliminate errors in visual interpretation,and make it possible to obtain closer-to-reality numerals that are compulsory for any measurement process.
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Vascular architecture:is it a helpful histopathological biomarker for hepatocellular carcinoma? |
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| GRIZZI Fabio,FRANCESCHINI Barbara,FIAMENGO Barbara,RUSSO Carlo,DIOGUARDI Nicola. Vascular architecture:is it a helpful histopathological biomarker for hepatocellular carcinoma?[J]. Journal of Zhejiang University. Science. B, 2007, 0(4) |
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| Authors: | GRIZZI Fabio FRANCESCHINI Barbara FIAMENGO Barbara RUSSO Carlo DIOGUARDI Nicola |
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| Affiliation: | GRIZZI Fabio1,FRANCESCHINI Barbara1,FIAMENGO Barbara2,RUSSO Carlo1,DIOGUARDI Nicola1 |
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| Abstract: | Hepatocellular carcinoma(HCC) remains one of the major public health problems throughout the world.Although originally associated with tumorigenic processes,liver angiogenesis has also been observed in the context of different liver in-flammatory,fibrotic,and ischemic conditions.Here we investigate the fractal dimension as a quantitator of non-Euclidean two-dimensional vascular geometry in a series of paired specimens of primary HCC and surrounding non-tumoral tissue,and discuss why this parameter might provide additional information regarding cancer behavior.The application of fractal geometry to the measurement of liver vascularity and the availability of a computer-aided quantitative method can eliminate errors in visual interpretation,and make it possible to obtain closer-to-reality numerals that are compulsory for any measurement process. |
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| Keywords: | Liver Angiogenesis Cancer Fractals Geometry Biomarkers |
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