4-碘乙酰苯胺的合成研究

以苯胺为起始原料,用冰醋酸将其乙酰化后,碘化钾为碘化剂,以温和的氧化剂双氧水作为碘化反应的活化剂,以CH3OH-H2O溶液为溶剂,在一定的反应条件下合成了4-碘乙酰苯胺,最佳反应条件为:H2O-CH3OH体积比为3:1,氧化剂用量与原料用量摩尔比为2:1,反应时间为6 h,反应温度75℃,4-碘乙酰苯胺的最高产率可达到86.7%。该方法反应步骤少,条件温和,选择性较好,产率高且绿色环保。

Study on the Synthesis of 4-Iodine Acetanilide

Firstly,aniline is acetylated with acetic acid,then the mild oxidant hydrogen peroxide is used as an activator of iodide reaction and the potassium iodide is used as iodine agent in the mixture of water and methanol.Under certain conditions,we get 4-iodine Acetanilide.The optimum reaction conditions are determined as follows: volume ratio of alcohol to water being 1:3,the ration of oxidant to raw materials being 2:1,reaction time being 6 h,the reaction temperature being 75 ℃,under these conditions the maximum yield is 86.7%.This method has some advantages.Less reaction steps are needed.The reaction is under mild conditions with good selectivity and high yield,moreover,it is environmental friendly.