微波辐射合成1,4-二(1-苯基-1,2,3,4-四氮唑-5-硫代甲基)苯的研究

研究了以异硫氰酸苯酯、叠氮化钠、对二氯苄为主要原料,在微波辐射条件下合成1,4-二(1-苯基-1,2,3,4-四氮唑-5-硫代甲基)苯,并对影响反应因素进行了研究。结果表明:n(对二氯苄):n(1-苯基-5-巯基四氮唑)物质的量比为1:3,微波辐射时间为8 min,微波辐射功率为500 W,水用量50 mL时,反应条件最优化,产率可达90.5%。

Study on Synthesis of 1,4-Bis(1-Phenyl-1,2,3,4-Tetrazole-5-Thio) Benzene under Microwave Irradiation

The 1,4-bis(1-phenyl-1,2,3,4-tetrazole-5-thio) Benzene was synthesized by isothiocyanatobenzene,sodium azide and 1,4-Bis(chloromethyl)benzene by the microwave irradiation.The influential factors on the reaction were investigated.The experimental results indicated the optimum conditions were as fllows: molar ratio of 1-phenyl-5-thio-tetrazole and 1,4-Bis(chloromethyl)benzene was 1:3,microwave power was 500 W,the time of radiation was 8 min and the dosage of the water was 50 mL.Under above conditons,the yield reached 90.5%.