| Adaptive designs for sequential experiments |
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| 引用本文： | 林正炎,张立新. Adaptive designs for sequential experiments[J]. Journal of Zhejiang University. Science. B, 2003, 0(2) |
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| 作者姓名： | 林正炎 张立新 |
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| 作者单位： | Department of Mathematics，Zhejiang University，Hangzhou 310028，China |
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| 基金项目： | ProjectsupportedbytheNationalNaturalScienceFoundationofChina (Nos.195 710 2 1and 10 0 710 72 ) |
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| 摘 要： | ＩＮＴＲＯＤＵＣＴＩＯＮＴｒａｄｉｔｉｏｎａｌｄｅｓｉｇｎｓｆｏｒｃｌｉｎｉｃａｌｔｒｉａｌｓｕｓｅｔｈｅｂａｌａｎｃｅｄ (ｏｒ 50 50 )ａｌｌｏｃａｔｉｏｎｏｆｐａｔｉｅｎｔｓｔｏｔｒｅａｔｍｅｎｔｓ.Ｆｏｒｅｘａｍｐｌｅ ,ｉｎａｔｒｉａｌｔｏｃｏｍｐａｒｅｅｘｐｅｒｉｍｅｎｔａｌｔｈｅｒａｐｙ (ｄｒｕｇ)ｔｏｐｌａｃｅｂｏ (ｃｏｎ ｔｒｏｌ) ,ａｓｔａｎｄａｒｄｆｅａｔｕｒｅｏｆｍｏｓｔｄｅｓｉｇｎｓｉｓｔｏｄｉｓｔｒｉｂｕｔｅｈａｌｆｏｆｐａｔｉｅｎｔｓｔｏｅａｃｈａｒｍ .Ｉｔｉｓｒｅａ ｓｏｎ…
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Adaptive designs for sequential experiments |
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| LIN Zheng-yan,ZHANG Li-xin. Adaptive designs for sequential experiments[J]. Journal of Zhejiang University. Science. B, 2003, 0(2) |
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| Authors: | LIN Zheng-yan ZHANG Li-xin |
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| Abstract: | Various adaptive designs have been proposed and applied to clinical trials, bio assay, psychophysics, etc.Adaptive designs are also useful in high cost engineering trials.More and more people have been paying attention to these design methods. This paper introduces several broad families of designs, such as the play-the-winner rule, randomized play-the-winner rule and its generalization to the multi-arm case, doubly biased coin adaptive design, Markov chain model. |
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| Keywords: | Clinical trial Adaptive designs (Randomized) Play-the-winner rule Biased coin design Markov chain Asymptotic properties Urn model. |
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