Antidiabetic and antioxidant effects of <Emphasis Type="Italic">Picrorhiza kurrooa</Emphasis> rhizome extracts in diabetic rats |
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Authors: | Shivkumar Chauhan Nirmalendu Nath Vinay Tule |
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Institution: | (1) Department of Biochemistry, Nagpur University, L.I.T. Premises, Amravati Road, Nagpur, 440010, India;(2) Eugeniks Genetic Research Institute, Lokmat Bhavan, Ramdaspeth, Nagpur, 440012, India;(3) Eugeniks, Genetic Research Institute, 106/A-wing, First floor, Lokmat Bhavan, Ramdaspeth, Nagpur, 440012, India |
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Abstract: | Picrorhiza kurrooa is mentioned in Ayurveda for the treatment of many disorders, but it has not been subjected to systematic
scientific investigations to assess its antidiabetic effect. The oral administration of aqueous and methanol extracts of P.
kurrooa rhizomes (250 and 500 mg / kg body weight / day) for 15 days significantly reduced blood glucose, glycosylated haemoglobin
and increased total hemoglobin, plasma insulin in alloxan-induced diabetes in albino rats. The treatment also showed significant
correction in the level of nitric oxide radicals, superoxide radicals, peroxynitrite radical, lipid peroxidation, glutathione,
glutathione reductase, glutathione-S-transferase, glutathione peroxidase, superoxide dismutase and catalase in the pancreas
of alloxan diabetic rats. |
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Keywords: | Picrorhiza kurrooa Antidiabetic Alloxan Antioxidant |
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