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| 耐力运动对ApoE 基因敲除小鼠一氧化氮系统的影响及其对AS形成的干预作用 | |
| 引用本文： | 张洪侠,刘善云,李宁,冯红,王洪涛,王敏,徐新女,王金环.耐力运动对ApoE 基因敲除小鼠一氧化氮系统的影响及其对AS形成的干预作用[J].天津体育学院学报,2010,25(2):122-124. |
| 作者姓名： | 张洪侠 刘善云 李宁 冯红 王洪涛 王敏 徐新女 王金环 |
| 作者单位： | 1. 天津体育学院,天津300381;天津中医药大学,临床实训教学部,天津300193 2. 天津体育学院,天津,300381 3. 天津市第一中心医院,卫生部危重病急救医学重点实验室,天津300192 |
| 摘 要： | 目的:以ApoE基因敲除(ApoE-/-)小鼠为动脉粥样硬化(AS)模型,观察耐力训练对ApoE-/-小鼠AS形成的干预作用及NO系统的影响,以探讨耐力运动抗AS的可能机制.方法:将24只8周龄ApoE-/-小鼠随机分为AS模型组和运动干预组,每组12只,运动组在活动跑台上进行耐力训练,实验持续14周后,测定两组小鼠主动脉斑块面积及病理变化、血清NO和血脂水平以及主动脉iNOS和eNOS蛋白表达.结果:运动组小鼠主动脉斑块面积显著小于对照组(P<0.01),血管壁及内膜损伤程度较对照组减轻,血清NO浓度和主动脉eNOS蛋白表达显著高于对照组(P<0.01),i-NOS蛋白表达显著低于对照组(P<0.05),血脂水平两组间无显著差异.结论:耐力运动通过增加eNOS蛋白表达、抑制iNOS蛋白表达和提高血中NO水平而发挥抗动脉粥样硬化的作用. |
| 关 键 词： | 耐力运动 ApoE基因敲除小鼠 动脉粥样硬化 一氧化氮 一氧化氮合酶 |
| 收稿时间： | 1/6/2010 12:00:00 AM |
| 修稿时间： | 3/3/2010 12:00:00 AM |
The Effect of Endurance Exercise on Nitric Oxide System in Apoe-Deficient Mice and Its Intervention from Atherosclerotisis |
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| ZHANG Hongxia,LIU Shanyun,LI Ning,FENG Hong,WANG Hongtao,WANG Min,XU Xinnv,WANG Jinhuan.The Effect of Endurance Exercise on Nitric Oxide System in Apoe-Deficient Mice and Its Intervention from Atherosclerotisis[J].Journal of Tianjin Institute of Physical Education,2010,25(2):122-124. | |
| Authors: | ZHANG Hongxia LIU Shanyun LI Ning FENG Hong WANG Hongtao WANG Min XU Xinnv WANG Jinhuan |
| Institution: | ZHANG Hongxia1,2,LIU Shanyun1,LI Ning1,FENG Hong1,WANG Hongtao1,WANG Min1,XU Xinnv3,WANG Jinhuan3 (1.Tianjin University of Sport,Tianjin 300381,China,2.Dept. of Clinical Training,Tianjin University of Chinese Medicine,Tianjin 300193,3.Key Lab of Emergence Medicine of MOH,Tianjin First Center Hospital,Tianjin 300192,China) |
| Abstract: | Objective: The influence of endurance exercise on the function of preventing from atherosclerosis formation and effects of endurance exercise on NO system in ApoE-deficient mice were investigated to probe possible mechanisms of anti-atherosclerosis by endurance exercise. Methods: Twenty-four 8 week old ApoE-deficient mice were selected and divided into atherosclerosis model group and exercise group randomly. There were twelve mice in each group. Mice of exercise group were trained on treadmill for fourteen ... |
| Keywords: | endurance exercise ApoE-deficient mice atherosclerosis nitric oxide nitric oxide synthase |
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