A facile synthesis of 2-aryloxypyrimidine derivatives via a tandem reductive amination/intermolecular S_NAr sequence |
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| Authors: | Hai-feng WU Pei-zhi ZHANG Jun WU |
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| Institution: | 1.Department of Chemistry, Zhejiang University, Hangzhou 310027, China;2.School of Biological and Chemical Engineering, Zhejiang University of Science and Technology, Hangzhou 310012, China |
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| Abstract: | A novel tandem reductive amination/intermolecular nucleophilic aromatic substitution (SNAr) sequence has been established for the synthesis of amine containing pyrimidine in formation of one carbon-oxygen and one carbon-nitrogen bonds in a one-pot fashion. Treatment of aldehyde with arylamine, 2-methanesulfonyl-4,6-dimeth-oxypyrimidine and sodium borohydride provides good overall yield. The p-toluenesulfonic acid (PTSA) can be used as activator and is generally needed in the reaction. Dioxane is the preferr... |
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| Keywords: | Reductive amination/intermolecular SNAr C-O and C-N bonds Amine Pyrimidine Herbicide |
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