| 心喘灵(xc-1)抗心律失常的实验研究 |
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| 引用本文： | 谢世荣,张宝恒.心喘灵(xc-1)抗心律失常的实验研究[J].大连大学学报,1991(1). |
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| 作者姓名： | 谢世荣 张宝恒 |
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| 作者单位： | 北京医科大学(谢世荣) |
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| 摘 要： | 心喘灵(xc-1)能明显对抗乌头硷,BaCl_2和结扎左冠状动脉前降支诱发大鼠的室性心率失常,并能降低大鼠再灌注诱发的心律失常。xc-1能降低离体大鼠右心房的自发频率。对大鼠心电图实验,证明 xc-1有负性频率怍用,负性传导作用,负性自律性、负性频率、负性传导作用可能是 xc-1抗心率失常作用的药理基础。
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| 关 键 词： | 心喘灵 奎尼丁 乌头硷 氯化钡 心律失常 |
Exqerimental Studies of Antiarrhihmic Actions of xc-1 |
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| Xie Shirong Zhong Baoher.Exqerimental Studies of Antiarrhihmic Actions of xc-1[J].Journal of Dalian University,1991(1). |
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| Authors: | Xie Shirong Zhong Baoher |
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| Institution: | Xie Shirong Zhong Baoher |
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| Abstract: | xc-1 could antagonized obviously ventricular arrhythmias induced by aconitine,barium chloride and ligation of left corohary artery in rats also could reduce arrhythmias induced by perfusion again in rats.xc-1 could reduce spontaneous frequency of isolated right auricle of rats.ECG experiments indicated that.xc-1 had negative chronotropic effects,negative automaticity effects and negative conduction effect.These actions of xc-1 were probably pharmacological basis for antiarrthmias. |
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| Keywords: | xc-1 Quinidine Aconitine Barium chloride Arrhythmia |
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