创伤应激与环核苷酸的关系

以体外循环手术作为创伤应激模式，采用放射免疫法测定了１６例低温麻醉体外循环手术者围术期７个时段的血浆ｃＡＭＰ、ｃＧＭＰ值，探讨其在应激状态下的变化及临床意义．发现随机体承受创伤刺激，特别是对心脏的手术操作及体外循环转流刺激强度的增减，ｃＡＭＰ及ｃＧＭＰ呈相应的变化．表明在体外循环手术这种特定的创伤模式下，对血浆环核苷酸的动态监察可作为病人机体、特别是心脏应激反应强度的一个综合参考指标

Relationship between Traumatic Stress and Cyclic Ribonucleotide

The plasma concentrations of cAMP and cGMP in seven phases of perioperative period were measured by radioimmunoassay in sixteen patients underwent cardiopulmonary bypass and hypothermic anesthesia. The purpose of this study was to explore their roles under the stress and their meaning in clinical practice. The result implied that plasma cAMP and cGMP have appeared the synchronous change with the intensity of traumatic stimulation. The cAMP and cGMP was mainly related to the operative menuvour in heart and cardiopulmonary bypass.It was suggested that dynamic observation of plasma cyclic ribonucleotide can be considered as a reference index complex of the intensity of stress reaction in patients underwent cardiopulmonary bypass used as a special traumatic mode.