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Mission-oriented biomedical research at the NIH
Authors:Bhaven N. Sampat
Affiliation:1. University of Michigan School of Information, Ann Arbor, MI, 48109, USA;2. Dept. of Philosophy, University of Chicago, Chicago, IL, 60637, USA;3. Committee on Conceptual and Historical Studies of Science, University of Chicago, Chicago, IL, 60637;4. Harvard Business School, Harvard University, Boston, MA, 02163, USA;5. Laboratory for Innovation Science at Harvard, Harvard University, Boston, MA, 02163, USA;6. Institute for Quantitative Social Science, Harvard University, Cambridge, MA, 02138, USA;7. Knowledge Lab, University of Chicago, Chicago, IL, 60637, USA;1. Icahn School of Medicine at Mount Sinai, New York, New York;2. Department of Geriatrics and Palliative Medicine, Icahn School of Medicine at Mount Sinai, New York, New York;3. Geriatrics Research and Clinical Care Center, James J Peters VA Medical Center, Bronx, New York;1. Manchester Institute of Innovation Research, Alliance Manchester Business School, University of Manchester, Manchester, United Kingdom;2. Western Norway University of Applied Sciences, Bergen, Norway;3. Deusto Business School, University of Deusto, Donostia-San Sebastian, Spain;4. Orkestra-Basque Institute of Competitiveness, University of Deusto, Donostia-San Sebastian, Spain
Abstract:The NIH (National Institutes of Health) is the largest single funder of biomedical research in the world. This paper documents tensions between the agency's health and science missions and considers how, in light of these, it has managed to sustain a level of bipartisan political support uncommon in U.S. health or research policy. It highlights the serendipity hypothesis, the presence of “safety valve” mechanisms that allow it to (on occasion) target research at particular diseases and priorities, and a broad and diverse set of constituencies as important to understanding the agency's political success. Through an in-depth look at the NIH allocation process, the paper also provides insights into how demand-side considerations can affect the direction of scientific research.
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