| 泛素-蛋白酶体系统的结构、作用和调控机制 |
| |
| 引用本文： | 金伟军,姚祥春,吕美巧,张礼星.泛素-蛋白酶体系统的结构、作用和调控机制[J].科技通报,2008,24(1):29-34. |
| |
| 作者姓名： | 金伟军 姚祥春 吕美巧 张礼星 |
| |
| 作者单位： | 浙江工业大学,生物与环境工程学院,杭州,310014 |
| |
| 基金项目： | 温州市科技局资助项目(S2006A008) |
| |
| 摘 要： | 应激是指机体对外界或内部的各种刺激所产生的非特异性应答反应。泛素通过泛素-蛋白酶体途径在应激蛋白的降解过程中发挥重要作用,从而使生物体适应各种胁迫并对之产生抗性。对泛素-蛋白酶体系统作用机理及其基因分子结构的阐明,将有助于途径特异性位点抑制剂的设计,本文介绍了泛素-蛋白酶体系统的组成结构、作用机理和调控机制。
|
| 关 键 词： | 泛素 蛋白酶体 蛋白酶解 去泛素化 |
| 文章编号： | 1001-7119（2008）01-0029-06 |
| 收稿时间： | 2006-11-10 |
| 修稿时间： | 2006年11月10 |
Structure, Effect and Regulation of the Ubiquitin-Proteasome System |
| |
| JIN Weijun,YAO Xiangchun,LU Meiqiao,ZHANG Lixing.Structure, Effect and Regulation of the Ubiquitin-Proteasome System[J].Bulletin of Science and Technology,2008,24(1):29-34. |
| |
| Authors: | JIN Weijun YAO Xiangchun LU Meiqiao ZHANG Lixing |
| |
| Abstract: | Stress was the nonspecial response of the organisms against the stimulation from the outside or inside of it.Ubiquitin played a vital role in the degrading of injured proteins through ubiquitin-proteasome system.In addition,organisms could adapt and become resistant to future heat stress.Illustrating the mechanism and the molecular structure of the ubiquitin-proteasome system would benefit rational molecular design of new specific-site-inhibitors.This paper introduced the structure,effect and regulation of the ubiquitin-proteasome system. |
| |
| Keywords: | Ubiquitin proteasome proteolysis deubiquitin |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
