Reminder treatments do not alleviate cue-to-consequence deficits

Using rats in a conditioned lick suppression preparation, six experiments were conducted in which the subjects were exposed to a single tone-LiCl pairing. Despite evidence from tone-shock conditioning that the tone was an adequate conditioned stimulus and evidence from taste-LiCl conditioning that the LiCl was an adequate unconditioned stimulus, no suppression to the tone was observed following the tone-LiCl pairing, a finding consistent with prior cue-to-consequence research. In each experiment, subjects receiving a tone-LiCl pairing were subsequently exposed to either the tone or LiCl outside the conditioning context in an attempt to reactivate a potentially latent tone-LiCl association. The parameters of these reminder treatments were chosen on the basis of their previously proven effectiveness in reversing such performance deficits as blocking, overshadowing, latent inhibition, and experimental amnesia. Although a variety of stimulus parameters were used in an effort to reverse the cue-to-consequence deficit, none of the experiments detected any tendency towards suppression by reminded subjects exposed to a tone-LiCl pairing. This uniform lack of reminder-induced recovery suggests that cue-to-consequence deficits reflect true acquisition failure rather than poor retrievability.