Polymorphisms of CYP1A1, GSTM1 and GSTT1 Loci as the Genetic Predispositions of Oral Cancers and Other Oral Pathologies: Tobacco and Alcohol as Risk Modifiers |
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| Authors: | Sumana Chatterjee Soujatya Dhar Bani Sengupta Ashish Ghosh Manas De Sumit Roy Sila Chakrabarti |
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| Affiliation: | (1) Thalassaemia Research Unit, Ramakrishna Mission Seva Pratishthan, Vivekananda Institute of Medical Sciences, 99, Sarat Bose Road, Kolkata, 700026, West Bengal, India;(2) Department of Oral and Maxillofacial Surgery, Ramakrishna Mission Seva Pratishthan, Vivekananda Institute of Medical Sciences, 99, Sarat Bose Road, Kolkata, 700026, West Bengal, India;(3) Dental Clinic, Ramakrishna Mission Seva Pratishthan, Vivekananda Institute of Medical Sciences, 99, Sarat Bose Road, Kolkata, 700026, West Bengal, India; |
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| Abstract: | Polycyclic aromatic hydrocarbons of tobacco require activation by phase I enzymes, such as cytochrome-P4501A1 (CYP1A1) to become an ultimate carcinogen, which are subjected to detoxification by phase II enzymes, especially glutathione S-transferases (GSTs). A study was designed to find whether genetic predisposition are risk modifiers of oral pathologies. The study included 102 cases with Oral Cancers (OCs), 68 cases with nonmalignant pathologies, 100 cases as control group. GSTM1 null genotype was associated with increased risk of OCs but not with benign pathologies. Deleted GSTT1 was associated with all pathologies. Both m1m2 and m2m2 polymorphisms of CYP1A1 were associated with oral pathologies. |
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| Keywords: | Detoxification Nonmalignant Risk modifiers Oral cancers Genotype |
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