Urinary proteomics as a novel tool for biomarker discovery in kidney diseases |
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| Authors: | Jing Wu Yi-ding Chen and Wei Gu |
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| Institution: | (1) Mosaiques diagnostics &; therapeutics, Mellendorfer Str. 7–9, 30625 Hannover, Germany;(2) Department of Renal and Cardiac Remodelling, Inserm, U858/I2MR, Team #5, 1 Avenue Jean Poulh?s, BP 84225, 31432 Toulouse Cedex 4, France;(3) Institut de M?decine Mol?culaire de Rangueil, Universit? Toulouse III Paul Sabatier, 31000 Toulouse, France |
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| Abstract: | Urine has become one of the most attractive biofluids in clinical proteomics,for its procurement is easy and noninvasive and it contains sufficient proteins and peptides. Urinary proteomics has thus rapidly developed and has been extensively applied to biomarker discovery in clinical diseases,especially kidney diseases. In this review,we discuss two important aspects of urinary proteomics in detail,namely,sample preparation and proteomic tech-nologies. In addition,data mining in urinary proteomics is also b... |
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| Keywords: | Clinical proteomics Urinary proteomics Biomarker Kidney diseases |
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