| 齐墩果酸和熊果酸C-28位官能团的结构修饰和表征 |
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| 引用本文： | 刘丹竹,王迪峰,宋蕾蕾,赵德千,周晓琳,赵龙铉.齐墩果酸和熊果酸C-28位官能团的结构修饰和表征[J].大连大学学报,2008,29(6):35-40. |
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| 作者姓名： | 刘丹竹 王迪峰 宋蕾蕾 赵德千 周晓琳 赵龙铉 |
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| 作者单位： | 1. 辽宁师范大学化学化工学院,辽宁,大连,116029
2. 辽宁师范大学化学化工学院,辽宁,大连,116029;辽宁师范大学生物技术与分子药物研发辽宁省重点实验室,辽宁,大连,116029 |
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| 摘 要： | 为了开发具有潜在保肝、抗炎和抗肿瘤活性的三萜类化合物,一些新的齐墩果酸和熊果酸衍生物通过对C-3位羟基的保护和去保护,C-28位羧基的修饰被合成。相关化合物的结构通过IR、^1H NMR、^13C NMR和HRMS进行了表征。
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| 关 键 词： | 齐墩果酸 熊果酸 衍生物 合成 |
Modification and Characterization of C-28 Functional Groups on Oleanolic Acid and Ursolic Acid |
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| LIU Dan-zhu,WANG Di-feng,SONG Lei-lei,ZHAO De-qian,ZHOU Xiao-lin,ZHAO Long-xuan.Modification and Characterization of C-28 Functional Groups on Oleanolic Acid and Ursolic Acid[J].Journal of Dalian University,2008,29(6):35-40. |
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| Authors: | LIU Dan-zhu WANG Di-feng SONG Lei-lei ZHAO De-qian ZHOU Xiao-lin ZHAO Long-xuan |
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| Institution: | LIU Dan-zhu, WANG Di-feng, SONG Lei-lei, ZHAO De-qian, ZHOU Xiao-lin, ZHAO Long-xuan (1. College of Chemistry and Chemical Engineering, Liaoning Normal University, Dalian 116029, China; 2. Liaoning Provincial Key Laboratory of Biotechnology and Drug Discovery, Liaoning Normal University, Dalian 116029, China) |
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| Abstract: | In order to develop potential hepatoprotective, anti-inflammatory and antitumor agents, new oleanolic acidand ursolic acid derivatives were synthesized through protection and de-protection hydroxyl group at C-3, modificationcarboxylic group at C-28 of oleanolic acid and ursolic acid. The structures of the compounds were confirmed by IR, 1HNMR, 13C NMR and HRMS. |
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| Keywords: | oleanolic acid ursolic acid derivatives synthesis |
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