| 5-L-孟氧基-丁烯内酯的合成研究 |
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| 引用本文： | 李森兰,邢硕. 5-L-孟氧基-丁烯内酯的合成研究[J]. 洛阳师范学院学报, 2006, 25(5): 61-62 |
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| 作者姓名： | 李森兰 邢硕 |
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| 作者单位： | 1. 洛阳师范学院化学系,河南洛阳,471022
2. 同济大学环境科学与工程学院,上海,200092 |
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| 摘 要： | 5-L-孟氧基-丁烯内酯是合成多个系列、具有生理活性化合物的重要中间体.按现有文献的方法,其单一构型的一次性合成产率在25%左右.催化剂以NaHSO4代替H2SO4,以少量硅胶除杂,通过“浓缩-石油醚结晶(R构型),母液再反应”的方法,使S构型逐步转化为R构型.从而不但省去了水洗的麻烦操作,而且单一构型的合成产率可达74.5%以上.
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| 关 键 词： | 5-L-孟氧基-丁烯内酯 NaHSO4催化 合成 结晶 |
| 文章编号： | 1009-4790（2006）05-0061-02 |
| 收稿时间： | 2006-01-08 |
| 修稿时间： | 2006-01-08 |
Synthesis of 5-Menthyloxy-Butenolides |
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| LI Shen-lan,XING Shuo. Synthesis of 5-Menthyloxy-Butenolides[J]. Journal of Luoyang Teachers College, 2006, 25(5): 61-62 |
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| Authors: | LI Shen-lan XING Shuo |
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| Abstract: | 5-menthyloxy-butenolides is an important intermediate multi-synthesized and physiologically active.According to the methods recorded in existing literature,the yield of a single-formation synthesis is 25%.The catalyst H_2SO_4 is replaced by NaHSO_4;silica gel is applied to impurity removal;S-formation is transformed to R-formation by the method of "condensation,petroleum ether crystallization(R-formation) and second mother liquor reaction".Consequently,the trouble of water wash is saved and the yield of single-formation synthesis is raised to over 74.5%. |
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| Keywords: | 5-menthyloxy-butenolides NaHSO_4 catalyst synthesis crystallization |
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