薏仁对小鼠细胞色素P4501A1酶活性硇影响 |
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引用本文: | 黄劲,李红梅.薏仁对小鼠细胞色素P4501A1酶活性硇影响[J].贵阳学院学报(自然科学版),2011,6(3). |
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作者姓名: | 黄劲 李红梅 |
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作者单位: | 贵阳医学院生物化学与分子生物学教研室,贵州贵阳,550004 |
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摘 要: | 研究薏仁对细胞色素P4501A1酶活性的影响,为探讨其代谢机制及药用作用提供依据。昆明种小鼠各40只,按18.2g/kg·d^-1灌胃给药,生理盐水对照给药,分别在3周、6周和9周后采用分光光度法测定小鼠肝微粒体CYPlAl的活性。结果是薏仁能降低CYPlAl酶活性,且呈时间依赖性,抑制率在6.35%-46.50%之间;并对CYPlAl酶活性的抑制不存在性别差异。结论是薏仁可明显降低CYPlAl酶活性,且无性别差异。
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关 键 词: | 薏仁 细胞色素P450CYPlAl 小鼠 |
Effects of Coix Lachrymal-jobi on the Activity of Cytochrome P450 1A1 in Mouse Liver |
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Abstract: | Objective: To investigate the effects of Coix Lachrymal -jobion the activity of cyteehrome P4501A1 in mouse liver. Method: Coix Lachrymal -jobiwas administered intragastrally to male and female mice at doses of 18.2g/kg · d ^- 1. Controlled group was given by O. 9% NaC1 solution. Then enzymatic activity of CYP1A1 was detected by spectro- photometry at 3rd,6th or 9th weeks. Results: Enzymatic activity of CYP1A1 was inhibited byCoix Lachrymal-jobiranging from 6.35% to 46.50%, and the time course revealed that the inhibition reached plateau level at 9th week. There were not differences in activity of CYP1Al.between the sexes induced byCoix Lachrymal -jobi. Conclusions: Coix Lachrymal -jobicould inhibit the activity of CYP1A1, and no sex difference. |
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Keywords: | Coix Lachrymal -jobi Cytochrome P4501A1 mice |
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