Piper sarmentosum as an antioxidant on oxidative stress in human umbilical vein endothelial cells induced by hydrogen peroxide |
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| Authors: | Abdul Hamid Hafizah Zakaria Zaiton Amom Zulkhairi Adenan Mohd Ilham Megat Mohd Nordin Nor Anita and Abdullah Mahdy Zaleha |
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| Institution: | (1) Department of Physiology, Faculty of Medicine, Universiti Kebangsaan Malaysia Medical Centre, Jalan Raja Muda Abdul Aziz, 50300 Kuala Lumpur, Malaysia |
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| Abstract: | Endothelial cell death due to increased reactive oxygen species(ROS) may contribute to the initial endothelial injury,which promotes atherosclerotic lesion formation.Piper sarmentosum(PS),a natural product,has been shown to have an antioxidant property,which is hypothesized to inhibit production of ROS and prevent cell injury.Thus,the present study was designed to determine the effects of PS on the hydrogen peroxide(H2O2)-induced oxidative cell damage in cultured human umbilical vein endothelial cells(HUVEC... |
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| Keywords: | Piper sarmentosum Human umbilical vein endothelial cells(HUVECs) Malondialdehyde Oxidative stress Antioxidant enzymes |
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