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| 牛磺酸锌对慢性染汞大鼠、小鼠学习记忆的影响 | |
| 引用本文： | 赵文涛,张顺三,高洁,李积胜. 牛磺酸锌对慢性染汞大鼠、小鼠学习记忆的影响[J]. 河北北方学院学报(医学版), 2009, 26(1) |
| 作者姓名： | 赵文涛 张顺三 高洁 李积胜 |
| 作者单位： | 1. 沧州医学高等专科学校解剖教研室,河北,沧州,061001 2. 河北省沧州市疾病预防控制中心,河北,沧州,061001 3. 武警医学院军事预防医学研究所,天津,300162 |
| 基金项目： | 天津市自然科学基金重点项目 |
| 摘 要： | 目的:探讨牛磺酸锌(TZC)拮抗汞对神经系统的损害作用.方法:选用健康Wistar大鼠64只,昆明种小鼠60只分别随机分组,对照组、染汞组、汞+TZC组,大鼠采用Y迷宫,小鼠采用穿梭实验,观察染汞组和不同浓度TZC组的鼠学习记忆能力的变化.结果:汞可导致大鼠学习记忆能力下降(P<0.05),不同浓度的TZC均可缓解汞致大鼠学习记忆能力下降(P<0.05).结论:TZC在一定程度上能拮抗汞对神经系统毒性作用. |
| 关 键 词： | 牛磺酸锌 汞 学习 记忆 |
Study on the Effects of Learning and Memory Ability for Rats and Mice Exposed to Chronic Mercury |
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| ZHAO Wen-tao,ZHANG Shun-san,GAO Jie,LI Ji-sheng. Study on the Effects of Learning and Memory Ability for Rats and Mice Exposed to Chronic Mercury[J]. Journal of Hebei North University:Medical Edition, 2009, 26(1) | |
| Authors: | ZHAO Wen-tao ZHANG Shun-san GAO Jie LI Ji-sheng |
| Abstract: | Objective:To study the different dosages of taurine-zinc coordination compound(TZC)on resisting the impairment of mercury(Hg)induced CNS damage.Methods:The chosen rats and mice were divided into control group,Hg group,Hg+TZC group.The effected differences for learning memory ability were observed with the Y maze test and shuttle before and after experiment.Results:Mercury can lead to decrease of leaning and memory ability(P< 0.05),each zinc-supplement group can mitigate the damage induced by mercury in different degree(P<0.05).Conclusions:The resistance effect of TZC on the toxic of Hg is related to the form of zinc-compound and the dosage of TZC. |
| Keywords: | TZC Mercury Learning Memory |
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