Sialic acid in cardiovascular diseases |
| |
Authors: | P K Nigam V S Narain Ajay Kumar |
| |
Institution: | (1) Department of Cardiology, King George’s Medical University, 226 003 Lucknow;(2) Department of Biochemistry, GSVM Medical College, Kanpur |
| |
Abstract: | Sialic acid, the acylated derivatives of 9-carbon sugar neuraminic acid, present as terminal component of oligosaccharide
chains of many glycoproteins and glycolipids, has been recognized to be involved in the regulation of a great variety of biological
phenomena. Studies have shown that serum sialic acid predicts both coronary heart disease and stroke mortality and reflects
the existence or activity of an atherosclerotic process. Most of the studies have shown an elevation in serum sialic acid
concentration in coronary heart disease and a positive correlation between the raised serum sialic acid and the severity of
the coronary lesions is observed. However, a few contradictory reports are also available. Racial differences in serum sialic
acid have also been reported and correlated with international differences in the prevalence of atherosclerosis. Reduced sialic
acid content of platelets, erythrocytes and lipoproteins may play important role in the pathogenesis of atherosclerosis. Elucidation
of the mechanism of alternation in sialic acid concentration may throw more light on its potential clinical utility. Hence
more studies are needed to designates sialic acid as a cardiovascular risk factor/marker. |
| |
Keywords: | Sialic Acid Cardiovascular diseases |
本文献已被 SpringerLink 等数据库收录! |
|