| 卡托普利原料药新工艺研究 |
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| 引用本文： | 赵文献,李高伟,孟乔俐,刘洁,张春艳,郭胜辉,张满仓. 卡托普利原料药新工艺研究[J]. 商丘师范学院学报, 2011, 0(12): 44-47 |
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| 作者姓名： | 赵文献 李高伟 孟乔俐 刘洁 张春艳 郭胜辉 张满仓 |
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| 作者单位： | 商丘师范学院化学系商丘师范学院有机新材料合成重点实验室; |
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| 基金项目： | 国家自然科学基金(No.20972091)资助项目; 河南省教育厅自然科学研究计划(No.201lBl50029)资助项目 |
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| 摘 要： | 以天然易得的L-脯氨酸为原料,经N-酰化,Baylis-Hillman反应,不对称氢化,巯基化等四步反应,高效地开发了一条不对称合成卡托普利的新方法,其化学结构通过IR和1H NMR进行了表征.
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| 关 键 词： | 卡托普利 L-脯氨酸 新工艺 不对称合成 |
A new technology for synthesis of captopril as API |
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| ZHAO Wenxian,LI Gaowei,MENG Qiaoli,LIU Jie,ZHANG Chunyan,GUO Shenghui,ZHANG Mancang. A new technology for synthesis of captopril as API[J]. Journal of Shangqiu Teachers College, 2011, 0(12): 44-47 |
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| Authors: | ZHAO Wenxian LI Gaowei MENG Qiaoli LIU Jie ZHANG Chunyan GUO Shenghui ZHANG Mancang |
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| Affiliation: | ZHAO Wenxian,LI Gaowei,MENG Qiaoli,LIU Jie,ZHANG Chunyan,GUO Shenghui,ZHANG Mancang(Department of Chemistry and Key Laboratory of New Organic Materials Synthesis,Shangqiu Teachers College,Shangqiu 476000,China) |
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| Abstract: | A new and efficient asymmetric synthesis of active pharmaceutical ingredients(API) named Captopril,was described,and Captopril was achieved by N-acylation,Baylis-Hillman reaction,asymmetric hydrogenation and thiolation in high optical purity from nature L-proline.The chemical structure of Captopril was confirmed by IR and 1H NMR. |
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| Keywords: | Captopril L-proline new technology asymmetric synthesis |
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