| Integrins mediating bone signal transduction |
| |
| 作者姓名： | HE Chuanglong WANG Yuanliang YANG Lihu ZHANG Jun Key Laboratory for Biomechanics & Tissue Engineering Under the Ministry of Education Chongqing University Chongqing P.R. China Bioengineering College Chongqing University Chongqing |
| |
| 作者单位： | HE Chuanglong 1，2，WANG Yuanliang 1，2，YANG Lihua 1，2，ZHANG Jun 1，2 1Key Laboratory for Biomechanics & Tissue Engineering Under the Ministry of Education，Chongqing University，Chongqing 400030，P.R. China 2Bioengineering College，Chongqing University，Chongqing 400030，P.R. China |
| |
| 摘 要： | 1.IntroductionInteractionsbetweenbonecellsandtheirextra-cellularmatrix(ECM)arecrucialinregulatingbonecellsadhesion,growth,migration,anddifferentiation.Amongtheseinteractions,thedirectcell-matrixattach-mentisthefundamentalofothercellbehaviors.BiochemicalandmechanicalsignalsfromtheECMcanbetransducedtocellinteriorviasomecell-surfacetransmembranereceptors.Severalfamiliesofreceptorsinvolvingintegrin,cadherin,selectinandimmuno-globulinsuperfamilyarerecognized.Recentstudieshavesuggestedthatintegri…
|
| 关 键 词： | 额外细胞矩阵 信号转导 整合蛋白中介 骨骼吸收 骨骼构成 |
Integrins mediating bone signal transduction |
| |
| HE Chuanglong,WANG Yuanliang,YANG Lihu,ZHANG Jun,Key Laboratory for Biomechanics & Tissue Engineering Under the Ministry of Education,Chongqing University,Chongqing,P.R. China Bioengineering College,Chongqing University,Chongqing.Integrins mediating bone signal transduction[J].Journal of Chongqing University,2004,3(1):55-60. |
| |
| Authors: | He Chuanglong WANG Yuanliang Yang Lihu ZHANG Jun |
| |
| Abstract: | Integrin-mediated adhesions play critical roles in diverse cell functions. Integrins offers a platform on which mechanical stimuli, cytoskeletal organization, biochemical signals can concentrate. Mechanical stimuli transmitted by integrins influence the cytoskeleton, in turn, the cytoskeleton influences cell adhesion via integrins, then cell adhesion results in a series of signal transduction cascades. In skeleton, integrins also have a key role for bone resoption by osteoclasts and reformation by osteoblasts. In present review, the proteins involved in integrin signal transduction and integrin signal transduction pathways were discussed, mainly on the basic mechanisms of integrin signaling and the roles of integrins in bone signal transduction, which may give insight into new therapeutic agents to all kinds of skeletal diseases and new strategies for bone tissue engineering. |
| |
| Keywords: | integrin signal transduction bone absoption bone formation signal transduction bone tissue engineering insight therapeutic agents diseases strategies basic mechanisms signaling proteins integrin present review role osteoclasts reformation osteoblasts skeleton results series |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
| 点击此处可从《重庆大学学报(英文版)》浏览原始摘要信息 |
| 点击此处可从《重庆大学学报(英文版)》下载免费的PDF全文 |
