Immuno-Modulatory Effect and Therapeutic Potential of <Emphasis Type="Italic">Brugia malayi</Emphasis> Cystatin in Experimentally Induced Arthritis |
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| Authors: | Ravi Shankar Prasad Yadav Vishal Khatri Nitin Amdare Kalyan Goswami V B Shivkumar Nitin Gangane Maryada Venkata Rami Reddy |
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| Institution: | 1.Department of Biochemistry & JB Tropical Disease Research Center,Mahatma Gandhi Institute of Medical Sciences,Sevagram,India;2.Department of Pathology,Mahatma Gandhi Institute of Medical Sciences,Sevagram,India |
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| Abstract: | Helminths are known to modulate host’s immune system and understanding this modulation can help in identification of novel therapeutic agents for autoimmune diseases. In this study, we have assessed the immune-modulatory activity and the therapeutic effect of Brugia malayi recombinant cystatin (rBmCys) in methylated BSA (mBSA) induced arthritis using rodent model. Administration of rBmCys has suppressed the severity of mBSA-arthritis in mastomys by reducing paw swelling and other clinical disease parameters as evident from significantly decreased arthritic index. The anti-arthritic effect of rBmCys was also confirmed by decreased histopathological score for synovitis, bone erosion and fibrosis in the tissue sections of paws. Further, this therapeutic effect of cystatin was found to be associated with significantly decreased production of IFN-γ and TNF-α and increased release of IL-4 and IL-10 cytokines. These results implied that rBmCys treatment has alleviated mBSA-induced arthritis and thus can be a promising alternative agent for the treatment of arthritis. |
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| Keywords: | Brugia malayi cystatin Methylated BSA Rheumatoid arthritis Therapeutic effect |
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