Review Article: Recent advancements in optofluidic flow cytometer |
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Authors: | Cho Sung Hwan Godin Jessica M Chen Chun-Hao Qiao Wen Lee Hosuk Lo Yu-Hwa |
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Institution: | 1Materials Science and Engineering Program, University of California San Diego, La Jolla, California 92093-0418, USA;2Department of Electrical and Computer Engineering, University of California San Diego, La Jolla, California 92093-0407, USA;3Department of Bioengineering, University of California San Diego, La Jolla, California 92093-0412, USA |
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Abstract: | There is an increasing need to develop optofluidic flow cytometers. Optofluidics, where optics and microfluidics work together to create novel functionalities on a small chip, holds great promise for lab-on-a-chip flow cytometry. The development of a low-cost, compact, handheld flow cytometer and microfluorescence-activated cell sorter system could have a significant impact on the field of point-of-care diagnostics, improving health care in, for example, underserved areas of Africa and Asia, that struggle with epidemics such as HIV∕AIDS. In this paper, we review recent advancements in microfluidics, on-chip optics, novel detection architectures, and integrated sorting mechanisms. |
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