急性胰腺炎时血浆内毒素的变化及清下方的影响

本文是对急性胰腺炎血浆内毒素含量测定的前瞻性研究,共观察患者24例,入院时病情按 Ranson 指标分为轻、重二组并随机分为常规治疗组与加用中药清下方的中西医结合治疗组。对各自血浆中的内毒素含量进行组间及治疗前后对比,并以50名正常人作为对照组。结果显示:急性胰腺炎病例血浆内毒素含量为:0.174±0.123Eu/mL;正常对照为:0.0785±0.027Eu/mL,二者差异显著(P<0.05)。按病情分型,轻型组内毒素含量为:0.160±0.099Eu/mL,而重型组则达:0.261±0.169Eu/mL,两组间也有显著差异(P<0.05)。经中西医结合治疗可使血浆内毒素含量明显减少(P<0.05).但常规治疗前后的差异不明显(P>0.05)。研究表明:急性胰腺炎时可使血浆内毒素水平明显升高,其含量与病情的轻重程度关系密切。在常规治疗中加用中药清下方则有使血浆内毒素水平降低的作用。

A Clinical Study of the Effect of Qing Xia Fang on Endotoxaemia in Acute Pancreatitis

A prospective study of plasms endotoxin was conductedin twntyfour patients with acute pancreatitisand fifty normal controls.Twnty-four patients were randomly divided into two groups.Each group contains twelve patients.One group was treltedwith general therapy,the other was treated as the same but combined with Chinese medicine Qing xia fang.The endotoxin was measured regularly in both groups. The result indicatod that:the level of plasms endotoxinin acute pancreatitis rose remarkably than control(P<0.05)and correlated to the severity of acute pancreatitis and its systemic complication.There is a periodic character in the elecation of plasma endotoxin can be reduced wifh Qing Xia Fang,Which means that it may be benificial to the treatment of endo—toxaemia in acute pancreatitis.