Effects of flaxseed(Linum usitatissimum) chutney on gamma-glutamyl transpeptidase and micronuclei profile in azoxymethane treated rats |
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Authors: | K. A. Faseehuddin Shakir Basavaraj Madhusudhan |
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Affiliation: | (1) Nutraceuticals Research Group Department of Studies and Research in Biochemistry and Food Technology, Kuvempu University, P.G. Centre, Shivagangotri, 577 002 DAVANAGERE, Karnataka, India |
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Abstract: | Antioxidant property of flaxseed chutney was evident by decreasing lipid peroxidation (TBARS) and predictor enzyme γ-glutamyl transpeptidase profile and micronuclei formation in azoxymethane treated rats. After 10 weeks, rats fed with either fiber-free basal diet or Antioxidant diet exhibited over sevenfold increase in γ-glutamyl transpeptidase activity and nearly fourfold increase in micronuclei load in comparison to controls (p<0.001). A significant reduction in both γ-glutamyl transpeptidase level (52%) and micronuclei formation (47%) was observed in fiber-free basal diet/Antioxidant diet/flaxseed chutney diet fed rats. Relative to rats fed fiber-free basal diet, the profile of γ-glutamyl transpeptidase and micronuclei load was not significantly altered. |
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Keywords: | Flaxseed chutney Micronuclei γ -glutamyl transpeptidase profile Azoxymethane TBARS |
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