高压静电纺丝法制备磁响应阿司匹林镇痛贴的综合性实验设计

该文设计了以聚乳酸(polylactic acid,PLA)为基材,阿司匹林为模型药物,磁性粒子(Fe3O4)响应的静电纺丝法制备具有磁响应性的药物缓释纳米纤维镇痛贴,避免了所载药物在临床应用中存在的不良反应及其他不足。同时,对样品的纤维形貌、体外缓释、控释等性能进行测试。结果表明,利用静电纺丝方法制备的阿司匹林镇痛帖具有较好的药物包封率,在体外的缓释时间能够达到72 h以上,同时给予外加磁场时,能够加速药物的释放,具有磁响应性能。该实验项目结合了药学、材料科学、化学与机械工程等诸多学科,具有综合性和可操作性,作为制药工程专业本科生实践教学综合性实验项目,可培养学生的综合技能和创新能力。

Comprehensive experimental design of magnetic response aspirin analgesic patch prepared by high voltage electrospinning

In this paper, an electrospinning method with polylactic acid(PLA) as the substrate, aspirin as the model drug, and magnetic particles(Fe3O4) as the response is designed to prepare drug sustained-release nanofiber analgesic patch with magnetic response, which can avoid the adverse reactions and other shortcomings of the drug in clinical application. At the same time, the fiber morphology, in-vitro release and controlled release properties of the samples are tested. The results show that aspirin analgesic paste prepared by electrospinning method has good drug entrapment efficiency. The sustained-release time in vitro can reach more than 72 h, and at the same time, the external magnetic field can accelerate the drug release and has magnetic response performance. This experimental project combines many subjects such as pharmacy, material science, chemistry and mechanical engineering, which is comprehensive and operable. As a comprehensive experimental project of practical teaching for undergraduates majoring in pharmaceutical engineering, it can cultivate students’ comprehensive skills and innovation ability.