Complex pathologies of angiotensin II-induced abdominal aortic aneurysms |
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Authors: | Daugherty Alan Cassis Lisa A Lu Hong |
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Institution: | (1) Graduate Interdisciplinary Program in Biomedical Engineering, The University of Arizona, Tucson, AZ, USA;(2) BIO5 Institute, The University of Arizona, Tucson, AZ, USA;(3) Department of Cell Biology and Anatomy, The University of Arizona, Tucson, AZ, USA;(4) Department of Aerospace and Mechanical Engineering, The University of Arizona, Tucson, AZ, USA;(5) Department of Biomedical Engineering, The University of Arizona, 1130 N. Mountain, PO Box 210119, Tucson, AZ 85721-0119, USA; |
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Abstract: | Angiotensin II (AngII) is the primary bioactive peptide of the renin angiotensin system that plays a critical role in many
cardiovascular diseases. Subcutaneous infusion of AngII into mice induces the development of abdominal aortic aneurysms (AAAs).
Like human AAAs, AngII-induced AAA tissues exhibit progressive changes and considerable heterogeneity. This complex pathology
provides an impediment to the quantification of aneurysmal tissue composition by biochemical and immunostaining techniques.
Therefore, while the mouse model of AngII-induced AAAs provides a salutary approach to studying the mechanisms of the evolution
of AAAs in humans, meaningful interpretation of mechanisms requires consideration of the heterogeneous nature of the diseased
tissue. |
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Keywords: | Abdominal aortic aneurysms Angiotensin II Pathologies Mouse |
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