肌膜Na+,K+-ATP酶与骨胳肌运动能力

利用文献资料法，分析了Na^ 、K^ 平衡能力与骨骼肌疲劳的关系，认为肌膜上的Na^ -K^ -ATP酶是维持肌纤维结构和功能的重要蛋白质，Na 、一些激素、递质通过复杂的信号转导机制对Na^ ，K^ -ATP酶活性进行调节。周期性训练刺激可以增加肌纤维细胞膜上酶的数量和活性，产生良性适应。研究表明疲劳时Na^ ，K^ -ATP活性下降，Na^ 、K^ 调节能力不足，胞内K^ 持续丢失，胞外Na^ 内流，静息电位绝对值随运动时间延长明显下降，肌肉做功能力下降。有资料表明，运动中自由基产生增加，以多种方式攻击Na^ ，K^ -ATP酶和脂质双分子层，是疲劳时酶活性下降的重要原因。

Na+-K+-ATPase on Skeletal Sarcolemma and Peripheral Fatigue

From information of the papers, the authors researched on the relationship of neuromuscular fatigue and Na+,K+-ATPase. Na+,K+-ATPase on skeletal muscles cell coat is a key protein to keep muscle fiber cell's structure and function. Na+,some hormones and transmitter are regulators of Na+,K+-ATPase, which affects not only the property of resting potential, action potential, proper excitability, but also the property of contraction and relaxation. After period exercising, the activity and number of Na+,K+-ATPase and the exercise ability is enhanced. It is made clear that free radical explosion in exercise attack the Na+,K+-ATPase, making the Na+,K+-ATPase on the membrane downregulation.