Science Letters:Proteomic analysis of differentially expressed proteins in mice with concanavalin A-induced hepatitis |
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| Authors: | Xu-fei TAN Feng CHEN Shan-shan WU Yu SHI Dong-cheng LIU Zhi CHEN |
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| Institution: | Xu-fei TAN,Feng CHEN,Shan-shan WU,Yu SHI,Dong-cheng LIU,Zhi CHEN (State Key Laboratory for Diagnosis , Treatment of Infectious Diseases,the First Affiliated Hospital,School of Medicine,Zhejiang University,Hangzhou 310003,China) |
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| Abstract: | Objective:To find new protein biomarkers for the detection and evaluation of liver injury and to analyze the relationship between such proteins and disease progression in concanavalin A (Con A)-induced hepatitis.Methods:Twenty-five mice were randomly divided into five groups:an untreated group,a control group injected with phosphate buffered saline (PBS),and groups with Con A-induced hepatitis evaluated at 1,3 and 6 h.Two-dimensional gel electrophoresis (2-DE) and mass spectrometry (MS) were used to identif... |
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| Keywords: | Concanavalin A (Con A) Liver injury Protein Two-dimensional electrophoresis (2-DE) |
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