| 三七叶皂甙抗心律失常作用的实验研究 |
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| 引用本文： | 黄胜英,谢世荣,黄彩云,冷萍. 三七叶皂甙抗心律失常作用的实验研究[J]. 大连大学学报, 2001, 22(6): 82-84,87 |
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| 作者姓名： | 黄胜英 谢世荣 黄彩云 冷萍 |
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| 作者单位： | 大连大学,医学院,辽宁,大连,116622 |
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| 摘 要： | 三七叶皂甙（ＰＮＬＳ）２０ｍｇ／ｋｇ、４０ｍｇ／ｋｇ能明显对抗乌头碱２０ｕｇ／ｋｇ，ＢａＣｌ２２ｍｇ／ｋｇ和结扎左冠状动脉前降支诱发大鼠的室性心律失常．ＰＮＬＳ也能明显对抗ＣａＣｌ２－Ａｃｈ（ＣａＣｌ２ ０．６％＋Ａｃｈ０．００２５％）混合液１０ｍｌ／ｋｇ诱发小鼠心房纤颤或扑动．ＰＮＬＳ对大鼠心电图实验，证明有负性频率作用，负性传导作用．这些作用可能是ＰＮＬＳ抗心律失常作用的药理基础
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| 关 键 词： | 三本叶皂甙 奎尼丁 乌头碱 氯化钡 心律失常 |
| 文章编号： | 1008-2395(2001)06-0082-04 |
Antiarrhythmic Effect of Saponines of Leaf of Panax Notoginseng |
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| HUANG Sheng-ying,XIE Shi-rong,HUANG Cai- yun,LENG Ping. Antiarrhythmic Effect of Saponines of Leaf of Panax Notoginseng[J]. Journal of Dalian University, 2001, 22(6): 82-84,87 |
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| Authors: | HUANG Sheng-ying XIE Shi-rong HUANG Cai- yun LENG Ping |
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| Abstract: | Saponines of Leaf of Panax Notoginseng (PNLS) 20mg/kg, 40mg/kg could inhibit markedly the ventricular arrhythmias induced by aconitine 20ug/kg and BaCl2 2mg/kg and coronary ligation in rats. It also obviously reduced the incidence of atrium fibrillation produced by CaCl2- Ach (CaCl2 0.6% + Ach 0.0025%) 10ml/kg in mice. These actions were similar to quinidine. The ECG of the rats was significantly P-R changed after iv PNLS 40mg/kg. Hearts were reduced. The P-R and Q-T intervals were prolonged. |
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| Keywords: | PNLS Quinidine Aconitine BaCl2 arrhythmias |
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