纳洛酮对急性酒精中毒小鼠T—AOC的影响 |
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引用本文: | 井长勤,;张秀华,;郭静,;刘瑞,;霍晓东. 纳洛酮对急性酒精中毒小鼠T—AOC的影响[J]. 河南职业技术师范学院学报, 2008, 0(1): 57-58 |
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作者姓名: | 井长勤, 张秀华, 郭静, 刘瑞, 霍晓东 |
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作者单位: | [1]新乡医学院生命科学技术系,河南新乡453003; [2]河南农业大学生命科学学院,河南郑州450000 |
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摘 要: | 为探讨纳洛酮对急性酒精中毒小鼠总抗氧化能力T—AOC的影响。将小鼠分为空白组、急性酒精中毒小鼠模型组和解救组,解救组对急性酒精中毒小鼠注射酸纳络酮注射液。处理结束后,摘眼球取血,分离血浆,测血清中T—AOC活力。结果酒精中毒小鼠血清T—AOC活力降低,纳洛酮解救后T—AOC的活力升高显著(α=0.05),但仍未能回复到中毒之前的水平。结果表明,纳洛酮在恢复酒精中毒小鼠机体抗氧化能力方面有一定的效果,但未能大幅度扭转机体抗氧化能力降低的趋势。
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关 键 词: | 盐酸纳络酮 急性酒精中毒 总抗氧化能力 |
Influence of Naloxone Hydrochloride Injection on T - AOC in Acute Alcoholism Rats |
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Affiliation: | Jing Changqin ,et al. (1. Xinxiang Medical University, Xinxiang 453003, China) |
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Abstract: | To explore the influence of Naloxone Hydrochloride injection on T - AOC in acute alcoholism rats. Methods The rats were divided into three groups: control group, acute alcoholism group and rescuing group. After the eyeball was removed, the blood was collected andthe plasma was separated. The activity of T - AOC was detected. Results The activity of T - AOC of rescuing group was higher than that of acute alcoholism group, ( α= 0.05), but smaller than that of control group. Conclusion Naloxone Hydrochloride injection has some effect in restoring the activity of T - AOC, but cannot completely convert the liver damage induced by the high concentration of alcohol. |
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Keywords: | naloxone hydrochloride acute alcoholism T - AOC |
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