| 幽门螺杆菌感染蒙古沙土鼠疾病模型的建立 |
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| 引用本文： | 谢献胜,刘孟,王小波,李建基,彭大新. 幽门螺杆菌感染蒙古沙土鼠疾病模型的建立[J]. 泰州职业技术学院学报, 2011, 11(3): 78-81 |
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| 作者姓名： | 谢献胜 刘孟 王小波 李建基 彭大新 |
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| 作者单位： | 扬州大学兽医学院,江苏扬州,225009 |
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| 基金项目： | “抗幽门螺杆菌高免蛋的研制”;泰州市科技开发项目 |
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| 摘 要： | 利用蒙古沙土鼠建立幽门螺杆菌（Helicobacter pylori,Hp）NCTC 11637株胃内感染模型。感染方法有两种,方法Ⅰ是沙土鼠禁食18h后用50%酒精0.5mL预处理,6h后接种Hp,间隔12h、24h分别再次接种。方法Ⅱ的接种方法同方法Ⅰ,但接种后每日口服雷尼替丁（5m g/kg体重）。胃内接种H p后,于第7天、15天、35天、45天分别用Hp抗原酶联免疫诊断试剂盒、细菌培养和胃组织切片的方法观察沙土鼠胃内细菌感染情况和胃病理组织学变化。结果表明,给沙土鼠胃内灌服酒精以损伤胃黏膜并每日口服雷尼替丁,在人工接种35天后,胃内见有多量Hp生长,胃组织病变与Hp自然感染的病例相似。
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| 关 键 词： | 幽门螺杆菌 感染 蒙古沙土鼠 疾病模型 |
stablishment of Helicobacter Pylori Infection Model in Mongolian Gerbils |
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| XIE Xian-sheng,,LIU Meng,WANG Xiao-bo,LI Jian-ji,PENG Da-xin. stablishment of Helicobacter Pylori Infection Model in Mongolian Gerbils[J]. Journal of Taizhou Polytechnical Institute, 2011, 11(3): 78-81 |
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| Authors: | XIE Xian-sheng LIU Meng WANG Xiao-bo LI Jian-ji PENG Da-xin |
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| Affiliation: | XIE Xian-sheng1,2,LIU Meng1,WANG Xiao-bo1,LI Jian-ji1,PENG Da-xin1(1.College of Veterinary Medicine,Yangzhou University,Yangzhou Jiangsu 225009,China,2.Nat Wat spec Gen Pool,Jiangsu Animal Husbandry and Vetorinary College,Taizhou Jiangsu 225300,China) |
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| Abstract: | Two methods were used to establish models of Helicobacter pylori（NCTC11637） infection in the Mongolian gerbil stomach..The method Ⅰwas that the Mongolian gerbils were forbidden to eat for18 hours,then feed 0.5mL of 50% alcohol and inoculated Helicobacter |
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| Keywords: | helicobacter pylori infections mongolian gerbi disease mode |
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